Key result
Patients with manifest coronary artery disease had significantly higher carotid artery wall inhomogeneity compared to older subjects without cardiovascular disease (4.56 vs 3.83; P<0.001).
Why the study?
Does gray level wall inhomogeneity of the carotid artery intima-media layer differ between healthy subjects and patients with coronary artery disease?
Observational (n=146)
Does gray level wall inhomogeneity of the carotid artery intima-media layer differ between healthy subjects and patients with coronary artery disease?
Answers are grounded in this paper and cite their sources.
Measurement of gray level wall inhomogeneity in the carotid artery intima-media layer may serve as a novel surrogate marker for atherosclerotic burden, complementing standard intima-media thickness measurements.
OBJECTIVE: The process of atherosclerosis has been assessed increasingly by sonography in B-mode images of the carotid arteries. Carotid artery atherosclerosis is thought to be associated with major atherosclerotic diseases in other regions of the arterial bed, especially the coronary arteries. In addition to the intima-media thickening as an established surrogate parameter of the atherosclerotic wall process, changes of the sonographic morphologic pattern of the intima-media layer might reflect this process. METHODS: After automatic identification of the intimal and adventitial boundaries of the distal common carotid artery wall, the gray level inhomogeneity of the circumscribed intima-media area was quantified. Older subjects without cardiovascular disease (mean +/- SD, 66.2 +/- 3.8 years; n = 43) were compared with young subjects without cardiovascular disease (24.4 +/- 5.3 years; n = 34) and patients with manifest coronary artery disease (65.0 +/- 9.2 years; n = 69). RESULTS: Patients with coronary artery disease had a significantly higher intima-media thickness (0.92 +/- 0.21 mm; P < .05) and wall inhomogeneity (4.56 +/- 0.97; P < .001) than the old group (0.86 +/- 0.15 mm and 3.83 +/- 0.62). Both parameters were lowest in the young group (0.56 +/- 0.05 mm and 2.53 +/- 0.76; P < .05 for both parameters and groups). CONCLUSIONS: Measurement of gray level wall inhomogeneity of the intima-media layer of the common carotid artery may help discriminate between subjects with high and low atherosclerotic burden and may show age-related changes of the intima-media layer. This new quantitative parameter is thought to reflect the atherosclerotic wall process in addition to the intima-media thickness measurement.
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Sandrock et al. (2002) conducted an observational in Coronary artery disease and atherosclerosis (n=146). Manifest coronary artery disease vs. Older and young subjects without cardiovascular disease was evaluated on Gray level wall inhomogeneity of the intima-media layer (p=<.001). Patients with manifest coronary artery disease had significantly higher carotid artery wall inhomogeneity compared to older subjects without cardiovascular disease (4.56 vs 3.83; P<0.001).
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