Electrochemiluminescent Determination of Chlorphenamine Maleate Based on Ru(bpy)₃²⁺ Immobilized in a Nano‐Titania/Nafion Membrane

The immobilization of tris(2,2'‐bipyridyl)ruthenium(II) [Ru(bpy)₃²⁺ ] in a TiO2/Nafion nanocomposites membrane modified glassy carbon electrode (GCE) was achieved via both an ion‐exchange process and hydrophobic interactions .The surface‐confined Ru(bpy)₃²⁺ shows good electrochemical and photochemical activities. The Ru(bpy)₃²⁺ underwent reversible surface process and reacted with chlorphenamine maleate (CPM) to produce electrochemiluminescence. The modified electrode was used for the ECL determination of CPM. It showed good linearity in the concentration range from 2×10−8 g/mL to 1×10−6 g/mL (R=0.9995) with a detection 6×10−9 g/mL (S/N=3). The relative standard derivation (n=11) was 2%. This method is developed for the determination of CPM with simplicity and high sensitivity.