Key result
Primary central nervous system lymphoma significantly increased the risk of venous thromboembolism (OR 3.70) in hospitalized patients with newly diagnosed lymphoma, alongside bulky disease > 10 cm and ECOG performance status ≥ 2.
Population
857 adult patients with newly diagnosed lymphomas consecutively admitted and treated from 2004 to 2015…
Design
Cohort
Follow-up
median 14 months (range 6-15 months)
Authors
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VTE risk peaks in first month after lymphoma diagnosis; extends temporal patterns but should not yet alter practice.
Cohort (n=857)
No
Odds Ratio: 3.7 (95% CI 1.41–9.69)
p-value: p=0.008
In hospitalized patients with newly diagnosed lymphoma, primary CNS localization, bulky disease >10 cm, and reduced performance status (ECOG ≥2) are strong independent risk factors for venous thromboembolism.
Hohaus et al. (2018) conducted a cohort in Lymphoma (n=857). Primary central nervous system lymphoma (PCNSL) vs. Other lymphoma subtypes was evaluated on Incidence of venous thromboembolism (VTE) (OR 3.70, 95% CI 1.41-9.69, p=0.008). Primary central nervous system lymphoma significantly increased the risk of venous thromboembolism (OR 3.70) in hospitalized patients with newly diagnosed lymphoma, alongside bulky disease > 10 cm and ECOG performance status ≥ 2.
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