Key result
In-hospital acute kidney injury occurred in 8.0% of patients hospitalized for atrial fibrillation and was associated with an increased risk of major adverse cardiovascular events (OR 1.34; 95% CI 1.02-1.90; p=0.023).
Why the study?
The incidence and risk factors of in-hospital acute kidney injury in patients hospitalized for AF were unclear.
Observational (n=4,527)
Yes
Odds Ratio: 1.34 (95% CI 1.02–1.9)
p-value: p=0.023
In-hospital AKI is a frequent complication (8.0%) in patients hospitalized for AF and is associated with a significantly increased risk of major adverse cardiovascular events.
Warrants heightened AKI surveillance during AF admissions; leaves open whether risk-factor modification improves outcomes.
Background The incidence and the risk factors of in-hospitalized acute kidney injury (AKI) in patients hospitalized for atrial fibrillation (AF) were unclear.Methods The Improving Care for Cardiovascular Disease in China-AF (CCC-AF) project is an ongoing registry and quality improvement project, with 240 hospitals recruited across China. We selected 4527 patients hospitalized for AF registered in the CCC-AF from January 2015 to January 2019. Patients were divided into the AKI and non-AKI groups according to the changes in serum creatinine levels during hospitalization.Results Among the 4527 patients, the incidence of AKI was 8.0% (361/4527). Multivariate logistic analysis results indicated that the incidence of in-hospital AKI in patients with AF on admission was 2.6 times higher than that in patients with sinus rhythm (OR 2.60, 95% CI 1.77–3.81). Age (per 10-year increase, OR 1.22, 95% CI 1.07–1.38), atrial flutter/atrial tachycardia on admission (OR 2.16, 95% CI 1.12–4.15), diuretics therapy before admission (OR 1.48, 95% CI 1.07–2.04) and baseline hemoglobin (per 20 g/L decrease, OR 1.21, 95% CI 1.10–1.32) were independent risk factors for in-hospital AKI. β blockers therapy given before admission (OR 0.67, 95% CI 0.51–0.87) and non-warfarin therapy during hospitalization (OR 0.71, 95% CI 0.53–0.96) were associated with a decreased risk of in-hospital AKI. After adjustment for confounders, in-hospital AKI was associated with a 34% increase in risk of major adverse cardiovascular (OR 1.34, 95% CI 1.02–1.90, p = 0.023).Conclusions Clinicians should pay attention to the monitoring and prevention of in-hospital AKI to improve the prognosis of patients with AF.
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A 2021 study conducted an observational in Atrial fibrillation (n=4,527). In-hospital acute kidney injury (AKI) vs. No in-hospital AKI was evaluated on Major adverse cardiovascular (OR 1.34, 95% CI 1.02-1.90, p=0.023). In-hospital acute kidney injury occurred in 8.0% of patients hospitalized for atrial fibrillation and was associated with an increased risk of major adverse cardiovascular events (OR 1.34; 95% CI 1.02-1.90; p=0.023).
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