Key result
Higher white blood cell counts were significantly associated with greater brachial-ankle pulse wave velocity in Chinese hypertensive adults (adjusted β = 10; 95% CI, 8-13; P < .001).
Why the study?
Increased arterial stiffness is prevalent in hypertension and associated with CV risk, and increased WBC counts may be an independent risk factor for arterial stiffness and CV events.
Is higher white blood cell count associated with increased brachial-ankle pulse wave velocity in Chinese hypertensive adults?
Cross-Sectional (n=14,390)
Is higher white blood cell count associated with increased brachial-ankle pulse wave velocity in Chinese hypertensive adults?
Higher white blood cell counts are independently associated with increased arterial stiffness in hypertensive adults.
Higher WBC count was associated with greater baPWV in hypertensives; extends prior observational links but leaves causal and clinical implications open.
Increased arterial stiffness is highly prevalent in patients with hypertension and is associated with cardiovascular (CV) risk. Increased white blood cell (WBC) counts may also be an independent risk factor for arterial stiffness and CV events. The aim of the study was to investigate the relationship between differential WBC counts and brachial-ankle pulse wave velocity (baPWV) in hypertensive adults. A total of 14 390 participants were included in the final analysis. A multivariate linear regression model was applied for the correlation analysis of WBC count and baPWV. Higher WBC counts were associated with a greater baPWV: adjusted β = 10 (95% CI, 8-13, P < .001). The same significant association was also found when WBC count was assessed as categories or quartiles. In addition, the effect of differential WBC subtypes, including neutrophil count and lymphocyte count on baPWV, showed the similar results. These findings showed that baPWV has positive associations with differential WBC counts in hypertensive adults.
No takes yet. Share an insight, caveat, or question.
Jia et al. (2021) conducted a cross-sectional in Hypertension (n=14,390). White blood cell (WBC) counts was evaluated on Brachial-ankle pulse wave velocity (baPWV) (adjusted β = 10, 95% CI 8-13, p=<.001). Higher white blood cell counts were significantly associated with greater brachial-ankle pulse wave velocity in Chinese hypertensive adults (adjusted β = 10; 95% CI, 8-13; P < .001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: