Trichodermalongibrachiatum Rifai aggr. is a fungus reported to be antagonistic to the fungus Mycenacitricolor, the causative agent of the American leaf spot disease of coffee. We have investigated the metabolites produced when T. longibrachiatum is grown in liquid culture and have isolated the known compounds sorbicillin (2), bisvertinol (3), and bisvertinolone (4) as well as several new compounds including trichodimerol (1), an interesting new natural product possessing a proper axis of symmetry. The structure of trichodimerol (1) was determined by a combination of spectroscopic techniques, including 1H and 13C nuclear magnetic resonance, infrared, ultraviolet, circular dichroism, optical rotatory dispersion, and mass spectrometry, and by transformation to octahydrotrichodimerol (6) and symmetrical and unsymmetrical derivatives thereof. The relative stereochemistry of bisvertinol (3) and bisvertinolone (4) has been revised. The metabolites described are not biologically active against Mycenacitricolor.
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Andrade et al. (1992) studied this question.