Key result
The rapid Liatest D-dimer assay demonstrated 94.6% sensitivity (95% CI 92.0%-97.0%) and 35% specificity for diagnosing overall DVT at a 400 ng/mL cutoff.
Why the study?
Does the Liatest D-dimer assay accurately exclude deep venous thrombosis in patients with suspected DVT?
Population
464 patients admitted to the hospital with recent clinical signs of suspected deep venous thrombosis.
Comparison
Liatest D-dimer assay vs Standard plasma D-dimer ELISA measurement…
Design
Cohort
Authors
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May support DVT exclusion in suspected cases; leaves open prospective validation before practice change.
Observational (n=464)
Does the Liatest D-dimer assay accurately exclude deep venous thrombosis in patients with suspected DVT?
The rapid Liatest D-dimer assay is highly sensitive for proximal DVT and could replace ELISA for excluding proximal DVT, though both have lower sensitivity for distal DVT.
Escoffre‐Barbe et al. (1998) conducted an observational in Suspected deep venous thrombosis (DVT) (n=464). Liatest D-dimer assay vs. ELISA method was evaluated on Sensitivity for overall DVT at a cutoff level of 400 ng/mL (95% CI 92.0%-97.0%). The rapid Liatest D-dimer assay demonstrated 94.6% sensitivity (95% CI 92.0%-97.0%) and 35% specificity for diagnosing overall DVT at a 400 ng/mL cutoff.
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