Key result
Haemodialysis with a cuprammonium rayon membrane resulted in significantly lower platelet activation (CD62P 8.0 vs. 11.1) compared to a polysulfone membrane after 2 weeks.
Why the study?
Does haemodialysis with a cuprammonium rayon membrane reduce platelet activation compared to a polysulfone membrane in haemodialysis-treated patients?
RCT (n=14)
Crossover
Does haemodialysis with a cuprammonium rayon membrane reduce platelet activation compared to a polysulfone membrane in haemodialysis-treated patients?
Cuprammonium rayon membranes induce less platelet activation than polysulfone membranes during haemodialysis, which may have implications for cardiovascular risk in this population.
Answers are grounded in this paper and cite their sources.
May attenuate CV risk via lower platelet activation in haemodialysis; extends membrane biocompatibility data to activation markers.
BACKGROUND/AIM: Haemodialysis-treated patients are at a high risk of developing cardiovascular disease. Part of this risk may be attributable to the type of the dialysis membrane used. We evaluated whether different dialysis membranes differ with respect to platelet activation. METHODS: In a randomized crossover trial, the platelet activation was measured in 14 patients treated with two different dialyzers (cuprammonium rayon membrane and polysulfone membrane). We compared the platelet activation over the dialyzer and between dialyzers after several weeks of dialysis. RESULTS: There were no differences between the two dialyzers in platelet activation over the dialyzer. After 2 weeks, however, the expression of CD62P, CD63, and PAC-1 was statistically significantly lower after cuprammonium membrane treatment than after polysulfone membrane treatment (mean fluorescence intensity in arbitrary units 8.0 vs. 11.1, 2.64 vs. 4.01, and 5.61 vs. 9.74, respectively). CONCLUSION: Dialysis with a polysulfone membrane seems to lead to more platelet activation than dialysis with a cuprammonium membrane.
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Thijs et al. (2007) conducted an RCT in Haemodialysis (n=14). Cuprammonium rayon membrane vs. Polysulfone membrane was evaluated on Platelet activation (expression of CD62P). Haemodialysis with a cuprammonium rayon membrane resulted in significantly lower platelet activation (CD62P 8.0 vs. 11.1) compared to a polysulfone membrane after 2 weeks.
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