Key result
Filtral dialyser is linked to the least thrombocytopenia vs. other devices, despite augmented platelet aggregation.
Why the study?
The effects of different dialysers on platelet count, aggregation responses, and plasma beta-thromboglobulin during dialysis were not fully characterized.
How do different dialysers affect platelet count, aggregation, and beta-thromboglobulin during hemodialysis?
Observational
How do different dialysers affect platelet count, aggregation, and beta-thromboglobulin during hemodialysis?
Answers are grounded in this paper and cite their sources.
Different dialysers, including variations in membrane geometry and materials, differentially affect platelet activation and beta-thromboglobulin levels during hemodialysis.
Platelet count, platelet aggregation responses, and plasma beta-thromboglobulin were assessed before and at intervals during each study dialysis. As expected, modest thrombocytopenia was observed following treatment with all dialysers, but Filtral showed the least effect. Concordantly, modest increases in plasma beta-thromboglobulin were observed with all devices except Filtral (caveat: the device also seems to adsorb beta-thromboglobulin). Interpatient variability was more striking for platelet aggregation responses, and made it difficult to discern patterns; however, aggregation in response to ADP was augmented during haemodialysis with the Filtral device, and blunted when the G120 M was employed. Differences between hollow-fibre and parallel plate devices with the same membrane material suggest that membrane geometry, manufacturing residues, membrane support, or potting materials may also contribute to platelet activation.
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Ivanovich et al. (1993) conducted an observational in Haemodialysis. Dialysers (Filtral, G120 M) vs. Other dialysers was evaluated on Platelet count, platelet aggregation responses, and plasma beta-thromboglobulin. Haemodialysis with the Filtral device resulted in the least thrombocytopenia and beta-thromboglobulin increase compared to other dialysers, though it augmented ADP-induced platelet aggregation.
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