Key result
The combination of an ACE inhibitor and an angiotensin receptor blocker markedly improved coronary flow reserve in spontaneously hypertensive rats after 12 weeks of treatment.
Why the study?
Does the combination of an ACE inhibitor and an ARB improve coronary flow reserve in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats
Comparison
Combination of an angiotensin-converting enzyme… vs Normotensive Wistar Kyoto rats (reference)
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change clinical practice; hypothesis-generating for dual renin-angiotensin blockade in hypertensive heart disease.
Does the combination of an ACE inhibitor and an ARB improve coronary flow reserve in spontaneously hypertensive rats?
In a rat model of hypertension, combined ACE inhibitor and ARB therapy improved coronary flow reserve, suggesting potential benefits for hypertensive heart disease.
Edward D. Fröhlich (2001) studied Hypertension. Combination of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin-II (type 1) receptor blocker was evaluated on Coronary flow reserve. The combination of an ACE inhibitor and an angiotensin receptor blocker markedly improved coronary flow reserve in spontaneously hypertensive rats after 12 weeks of treatment.
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