January 1, 1979AJP Renal Physiology

Carbonic anhydrase-dependent bicarbonate reabsorption in the rat proximal tubule

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Why the study?

Does acetazolamide inhibit bicarbonate reabsorption in the rat proximal tubule?

Population

Rat proximal convoluted tubule (in vivo microperfusion model)

Comparison

Acetazolamide added to perfusion solution vs Control and t-butyl acetazolamide

Design

Preclinical

Authors

MLM. S. LucciUniversity of New Mexico DWDavid G. WarnockUniversity of Alabama at Birmingham FRF. C. RectorThe University of Texas Southwestern Medical Center

Discussion

Member takes

Implication

Acetazolamide abolishes rat proximal bicarbonate reabsorption; leaves open translation to human physiology or clinical use.

Structured PICO

Does acetazolamide inhibit bicarbonate reabsorption in the rat proximal tubule?

Population

Rat proximal convoluted tubule (in vivo microperfusion model)

Intervention

Acetazolamide (800 or 100 microM) added to perfusion solution

Comparator

Control (ultrafiltrate-like solution) and t-butyl acetazolamide (inactive congener)

Outcome

Reabsorption of total CO2 (JtCO2) and volume reabsorptive rate (JV)surrogate

Bicarbonate reabsorption in the rat proximal tubule is completely dependent on carbonic anhydrase, with no evidence for carbonic acid recycling or carbonic anhydrase-independent mechanisms.

Cite This Study

Lucci et al. (1979) studied this question.

synapsesocial.com/papers/6a97b1082855ae6cf374c8fe https://doi.org/10.1152/ajprenal.1979.236.1.f58

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Carbonic anhydrase-dependent bicarbonate reabsorption in the rat proximal tubule

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Carbonic anhydrase-dependent bicarbonate reabsorption in the rat proximal tubule

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider