Key result
Omentin-1 levels were more than two-fold higher in the pericardial effusion of patients with idiopathic pericarditis compared to controls undergoing elective cardiac surgery.
Case-Control
Proteomic analysis reveals elevated omentin-1 in pericardial effusion of patients with idiopathic pericarditis, suggesting a potential role in its molecular pathogenesis.
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Should not change practice; hypothesis-generating for omentin-1 in idiopathic pericarditis pathogenesis.
Pericardial fluid (PF) is often considered to be reflection of the serum by which information regarding the physiological status of the heart can be obtained. Some local and systemic disorders may perturb the balance between synthesis and discharge of PF and may cause its aberrant accumulation in the pericardial cavity as pericardial effusion (PE). PE may then lead to an increased intrapericardial pressure from which the heart function is undesirably affected. For some cases, the causes for the perturbance of fluid balance are well understood, but in some other cases, they are not apparent. It may, thus, be helpful to understand the molecular mechanisms behind this troublesome condition to elucidate a clinical approach for therapeutic uses. In this study, protein profiles of PEs from idiopathic pericarditis patients were analyzed. Control samples from patients undergoing elective cardiac surgery (ECS) were included for comparison. In addition to high abundant serum-originated proteins that may not hold significance for understanding the molecular mechanisms behind this disease, omentin-1 was identified and its level was higher for more than two-fold in PE of IP patients. Increased levels of omentin-1 in PE may open a way for understanding the molecular mechanisms behind idiopathic pericarditis (IP).
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Yavuz et al. (2014) conducted a case-control in Idiopathic pericarditis with pericardial effusion. Idiopathic pericarditis vs. Elective cardiac surgery (ECS) was evaluated on Omentin-1 levels in pericardial effusion (>2-fold higher). Omentin-1 levels were more than two-fold higher in the pericardial effusion of patients with idiopathic pericarditis compared to controls undergoing elective cardiac surgery.
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