Key result
Endothelin-1 immunoreactivity was detected within epithelial follicular cells of rat and porcine thyroid glands, with mean concentrations of 0.75 pg/mg and 1.5 pg/mg, respectively.
May suggest local ET-1 production in thyroid tissue; leaves open any role in human thyroid function or disease.
Endothelin-1 immunoreactivity (irET-1) was observed in rat and porcine thyroid glands. Using a radioimmunoassay for endothelin-1, the mean concentration in extracts of rat and porcine thyroid glands were 0.75 pg/mg +/- 0.03 (n = 4) and 1.5 pg/mg +/- 0.2 (n = 8) (mean +/- SE) respectively. Gel-filtration and reverse-phase HPLC showed that ir ET-1 eluted in a position identical to synthetic endothelin-1. In addition, immunohistochemical study showed that irET-1 is located within epithelial follicular cells. No immunostaining was seen in parafollicular C-cells nor in parathyroid.
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Colin et al. (1992) studied this question. Endothelin-1 immunoreactivity detection was evaluated on Endothelin-1 concentration in thyroid gland extracts. Endothelin-1 immunoreactivity was detected within epithelial follicular cells of rat and porcine thyroid glands, with mean concentrations of 0.75 pg/mg and 1.5 pg/mg, respectively.
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