July 1, 1992ReproductionOpen Access

Endothelin-like immunoreactivity in human endometrium

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Healthy endometrium (n=8). Intervention: Endothelin-like immunoreactivity (ET-IR) detection. Primary outcome: Presence and localization of endothelin-like immunoreactivity.

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Key result

Endothelin-like immunoreactivity was intensely detected in the cytoplasm of endometrial glands and vascular endothelium in all 15 sections from 8 women.

Population

Human endometrium and myometrium tissue sections

Design

Preclinical

Authors

ADAnthony P. Davenport CPC. van Papendrop PBPat J. Barker

Discussion

Member takes

Overview

Indicates possible local ET role in uterus; leaves open functional significance pending validation.

Study Design

Type

Observational (n=8)

Structured PICO

Population

8 women in the proliferative or secretory phase of the menstrual cycle whose endometrial tissue was analyzed for endothelin-like immunoreactivity.

Exposure

Immunocytochemical staining using primary antibodies against endothelin 1 (ET-1) and ET-3

Outcome

Detection and localization of endothelin-like immunoreactivity (ET-IR)surrogate

The demonstration of endothelin-like immunoreactivity in human endometrium suggests that endothelins may play a role in the control of the uterine vascular bed.

Cite This Study

Davenport et al. (1992) conducted an observational in Healthy endometrium (n=8). Endothelin-like immunoreactivity (ET-IR) detection was evaluated on Presence and localization of endothelin-like immunoreactivity. Endothelin-like immunoreactivity was intensely detected in the cytoplasm of endometrial glands and vascular endothelium in all 15 sections from 8 women.

synapsesocial.com/papers/6ab4814ac00cd19ff64d3682 https://doi.org/10.1530/jrf.0.0950623

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July 1, 1992ReproductionOpen Access

Endothelin-like immunoreactivity in human endometrium

View Full Paper

Ask AI

Bookmark

Key result

Endothelin-like immunoreactivity was intensely detected in the cytoplasm of endometrial glands and vascular endothelium in all 15 sections from 8 women.

Population

Human endometrium and myometrium tissue sections

Design

Preclinical

Authors

ADAnthony P. Davenport CPC. van Papendrop PBPat J. Barker

Discussion

Member takes

Overview

Indicates possible local ET role in uterus; leaves open functional significance pending validation.

Study Design

Type

Observational (n=8)

Structured PICO

Population

8 women in the proliferative or secretory phase of the menstrual cycle whose endometrial tissue was analyzed for endothelin-like immunoreactivity.

Exposure

Immunocytochemical staining using primary antibodies against endothelin 1 (ET-1) and ET-3

Outcome

Detection and localization of endothelin-like immunoreactivity (ET-IR)surrogate

The demonstration of endothelin-like immunoreactivity in human endometrium suggests that endothelins may play a role in the control of the uterine vascular bed.

Cite This Study

synapsesocial.com/papers/6ab4814ac00cd19ff64d3682 https://doi.org/10.1530/jrf.0.0950623

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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