Population
Human endometrial tissue and separated endometrial stromal and glandular epithelial cells in culture
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ET-1 as a modulator of endometrial function pending human validation.
Endothelin-1 is produced by endometrial stromal and glandular epithelial cells, with expression peaking during the premenstrual-menstrual phase and upregulated by TGF-beta and IL-1 alpha, suggesting a role in modulating endometrial blood flow.
Economos et al. (1992) studied this question.
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