Key result
Postpartum state markedly increases myometrial endothelin-1 production, suggesting a role in controlling placental bleeding.
Why the study?
The source of endothelin-1 production in rat uterus during pregnancy and its role in normal pregnancy were unclear.
Population
Rat uterus tissue during pregnancy and early postpartum
Comparison
Pregnant vs nonpregnant rats
Design
Immunohistochemistry, in situ hybridization, and Northern blot analysis
Authors
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May indicate local ET-1 role in gestational uterine adaptation; leaves open relevance to maternal cardiovascular physiology.
Kajihara et al. (1996) studied Pregnancy. Pregnancy and postpartum state vs. Nonpregnant state was evaluated on Localization and expression of ET-1 and prepro-ET-1 mRNA. Endothelin-1 production in rat myometrial cells significantly increases in the early postpartum period compared to nonpregnant states, suggesting a role in controlling placental bed bleeding.
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