Key result
Isoproterenol administration significantly increased velocity time integral and shunt fraction in dogs with atelectasis, with a significant correlation between their percentage changes (r2 = 0.50, P<0.001).
Why the study?
Does transesophageal echocardiography detect changes in regional pulmonary blood flow induced by vasoactive drugs in an experimental dog model of atelectasis?
Population
14 anesthetized and ventilated mongrel dogs with an induced atelectatic lesion
Comparison
Systemic administration of isoproterenol 0.05… vs Baseline measurements prior to drug…
Design
Preclinical, Randomized into an isoproterenol group or a dopamine group
Authors
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May support TEE for monitoring drug effects on pulmonary flow in atelectasis; leaves open human translation.
Does transesophageal echocardiography detect changes in regional pulmonary blood flow induced by vasoactive drugs in an experimental dog model of atelectasis?
Effect estimate: r2 = 0.50
p-value: p=<0.001
Transesophageal echocardiography is a useful method for detecting changes in regional pulmonary blood flow in atelectatic lung lesions.
Yatsu et al. (2008) studied Atelectatic lung lesion (n=14). Isoproterenol vs. Dopamine was evaluated on Velocity time integral (VTI) and shunt fraction (Qs/Qt) (r2 = 0.50, p=<0.001). Isoproterenol administration significantly increased velocity time integral and shunt fraction in dogs with atelectasis, with a significant correlation between their percentage changes (r2 = 0.50, P<0.001).