Key result
In Japanese patients with type 2 diabetes, increased common carotid artery intima-media thickness was independently associated with the presence of silent cerebral infarction (OR 4.16).
Why the study?
Is common carotid artery intima-media thickness (CCA-IMT) associated with silent cerebral infarction in Japanese patients with type 2 diabetes?
Cross-Sectional (n=217)
No
Is common carotid artery intima-media thickness (CCA-IMT) associated with silent cerebral infarction in Japanese patients with type 2 diabetes?
Odds Ratio: 4.16 (95% CI 1.37–12.62)
p-value: p=0.012
Common carotid artery intima-media thickness (CCA-IMT) is an independent risk factor for silent cerebral infarction in Japanese patients with type 2 diabetes.
CCA-IMT may mark silent cerebral infarction risk in type 2 diabetes; leaves open prospective validation before clinical adoption.
OBJECTIVE: We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS: The brain MRI study and the carotid ultrasonography were performed in a total of 217 consecutive Japanese subjects with type 2 diabetes. Various risk factors for SCI were examined using multiple logistic analyses. RESULTS: The SCI was found in 60.4% of the diabetic subjects. In the diabetic subjects, age, systolic blood pressure (SBP), pulse wave velocity, and CCA-IMT were significantly higher in the subjects with SCI than in those without it. Multiple logistic analyses indicated that age, SBP, and CCA-IMT were significant and independent risk factors of SCI in the diabetic subjects. CONCLUSIONS: CCA-IMT, but not pulse wave velocity, was independently associated with SCI in Japanese subjects with type 2 diabetes.
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Nomura et al. (2009) conducted a cross-sectional in Type 2 Diabetes and Silent Cerebral Infarction (n=217). Common carotid artery intima-media thickness (CCA-IMT) vs. Lower CCA-IMT was evaluated on Presence of silent cerebral infarction (SCI) on MRI (OR 4.16, 95% CI 1.37-12.62, p=0.012). In Japanese patients with type 2 diabetes, increased common carotid artery intima-media thickness was independently associated with the presence of silent cerebral infarction (OR 4.16).
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