Neonatally bursectomized chickens were seriously defective in antibody production to human red cells. When grafted with a bursa in a millipore chamber, significant restoration of antibody formation occurred. The antibody formed in grafted chickens was mercaptoethanol sensitive. An endocrine function for the bursa of Fabricius in respect to production of antibody is strongly indicated by these results.
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Janković et al. (1965) studied this question.