Key result
An implanted system delivering epidural electrical stimulation over the thoracic spinal cord restored blood pressure regulation and enabled a patient with multiple-system atrophy to stand and walk.
Why the study?
Orthostatic hypotension is a cardinal feature of multiple-system atrophy that provokes syncopal episodes preventing standing and walking.
Does an implanted epidural electrical stimulation system restore blood pressure regulation and mobility in a patient with multiple-system atrophy and orthostatic hypotension?
Case Report (n=1)
Does an implanted epidural electrical stimulation system restore blood pressure regulation and mobility in a patient with multiple-system atrophy and orthostatic hypotension?
An implanted epidural electrical stimulation system successfully restored blood pressure regulation and mobility in a patient with severe orthostatic hypotension due to multiple-system atrophy.
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood pressure and enable a patient with multiple-system atrophy to stand and walk after having lost these abilities because of orthostatic hypotension. This system involved epidural electrical stimulation delivered over the thoracic spinal cord with accelerometers that detected changes in body position. (Funded by the Defitech Foundation.).
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A 2022 study conducted a case report in Orthostatic hypotension in multiple-system atrophy (n=1). Implanted system involving epidural electrical stimulation over the thoracic spinal cord with accelerometers was evaluated on Restoration of blood pressure regulation and ability to stand and walk. An implanted system delivering epidural electrical stimulation over the thoracic spinal cord restored blood pressure regulation and enabled a patient with multiple-system atrophy to stand and walk.
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