What is the clinical evidence from this study?

Population: Atrial fibrillation (n=12). Intervention: Rapid atrioventricular pacing vs. Baseline. Primary outcome: Atrial effective refractory period (AERP) (p=< 0.0001).

November 1, 1999Pacing and Clinical Electrophysiology

Tachycardia Induced Electrical Remodeling of the Atria and the Autonomic Nervous System in Goats

Q: What are the key findings of this study?

Rapid atrioventricular pacing for 24 hours significantly shortened the atrial effective refractory period from 147 ms to 102 ms (P < 0.0001), and high vagal tone attenuated recovery.

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Key result

Rapid atrioventricular pacing for 24 hours significantly shortened the atrial effective refractory period from 147 ms to 102 ms (P < 0.0001), and high vagal tone attenuated recovery.

Authors

YBYuri BlaauwElectrophysiology RTRobert G TielemanElectrophysiology JBJan Leendert P. BrouwerInteruniversity Center for Social Science Theory and Methodology

Discussion

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Implication

May inform autonomic modulation of remodeling; hypothesis-generating and leaves open clinical translation.

PICO

Population

12 goats subjected to 24 hours of rapid atrioventricular pacing to investigate the role of the autonomic nervous system during electrical remodeling of the atria and recovery.

Intervention / Comparator

Rapid atrioventricular pacing vs Baseline (300:150 beats/min)

Primary Outcome

Atrial effective refractory period (AERP), p=< 0.0001

Main Result

Absolute Event Rate: 102% vs 147%

p-value: p=< 0.0001

Cite This Study

Blaauw et al. (1999) studied Atrial fibrillation (n=12). Rapid atrioventricular pacing vs. Baseline was evaluated on Atrial effective refractory period (AERP) (p=< 0.0001). Rapid atrioventricular pacing for 24 hours significantly shortened the atrial effective refractory period from 147 ms to 102 ms (P < 0.0001), and high vagal tone attenuated recovery.

synapsesocial.com/papers/6a97bb12c064c39a5174c06f https://doi.org/10.1111/j.1540-8159.1999.tb00386.x

Topics

Atrial fibrillation Persistent AF management AF ablation outcomes

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Tachycardia Induced Electrical Remodeling of the Atria and the Autonomic Nervous System in Goats

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Topics

Tachycardia Induced Electrical Remodeling of the Atria and the Autonomic Nervous System in Goats

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider