Key result
Acyclovir therapy and prophylaxis demonstrated possible beneficial effects in patients with primary and recurrent HSV-2 induced meningitis.
Why the study?
Does acyclovir improve outcomes in patients with primary and recurrent HSV-2 induced meningitis?
Case Report (n=5)
Does acyclovir improve outcomes in patients with primary and recurrent HSV-2 induced meningitis?
Acyclovir may have beneficial effects in treating primary and recurrent HSV-2 induced meningitis.
Hypothesis-generating for acyclovir in HSV-2 meningitis; prospective trials needed before clinical adoption.
We describe therapy with acyclovir in 1 patient with acute meningitis induced by herpes simplex virus type 2 (HSV-2) and in 1 patient with ascending myelitis in connection with meningitis after a primary genital HSV-2 infection. In addition, intermittent or continuous acyclovir prophylaxis against meningitis was employed in 3 patients with recurrent meningitis of probable HSV-2 etiology. Possible beneficial effects of the treatment were seen.
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Bergström et al. (1990) conducted a case report in Herpes Simplex Virus Type 2 Induced Meningitis (n=5). Acyclovir was evaluated. Acyclovir therapy and prophylaxis demonstrated possible beneficial effects in patients with primary and recurrent HSV-2 induced meningitis.
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