Key result
Hibernating mammals exhibit tolerance to hypothermia, resistance to dysrhythmia, and endurance of hypoxia, making them a potentially useful animal model for cardiovascular research.
Hibernating mammals may serve as valuable animal models for cardiovascular research due to their unique adaptations to hypothermia, hypoxia, and dysrhythmia.
Hibernating mammals merit exploration as CV models; leaves open translation of their adaptations to human therapeutics.
The hibernating mammals inherited a stable cardiovascular function as a result of adaptation to extreme external and internal environments during hibernation. 2. The cardiovascular function of a hibernator is characterized by three distinct features: (i) tolerance of hypothermia; (ii) resistance to dysrhythmia; and (iii) endurance of hypoxia. All these have clinical relevance in cardiovascular disorders in humans. 3. We suggest that the hibernating mammal can serve as a useful animal model for research into the cardiovascular system.
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Wang et al. (1999) conducted a review in Cardiovascular function. Hibernating mammal model was evaluated. Hibernating mammals exhibit tolerance to hypothermia, resistance to dysrhythmia, and endurance of hypoxia, making them a potentially useful animal model for cardiovascular research.
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