Key result
The heterozygous genotype (Ser49Gly) of the ADRB1 gene was significantly more prevalent in probands with primary atrial fibrillation (50.0%) compared to controls (19.2%; p<0.05).
Why the study?
Is the Ser49Gly polymorphism of the ADRB1 gene associated with an increased risk of primary or secondary atrial fibrillation?
Case-Control
Is the Ser49Gly polymorphism of the ADRB1 gene associated with an increased risk of primary or secondary atrial fibrillation?
Absolute Event Rate: 50% vs 19.2%
p-value: p=< 0.05
The heterozygous genotype (Ser49Gly) of the ADRB1 gene may serve as a genetic predictor for the development of primary or secondary atrial fibrillation.
May support ADRB1 as a candidate risk marker for primary AF; leaves open prospective validation and clinical utility.
AIM: The purpose of this study was to establish the probability and patterns of atrial fibrillation (AF) inheritance in families, and to find an association of primary and secondary AF with polymorphism Ser49Gly of the gene encoding beta1-adrenoreceptor (ADRB1). METHODS: We examined 103 probands with AF and 301 relatives. Physical examination, electrocardiography (ECG), echocardiography, Holter's monitoring of ECG, and other methods of functional diagnostics have been performed for all patients and their relatives. Genetic study has been performed using DNA extracted from peripheral blood leukocytes. RESULTS: Our results show that probands with primary AF and their relatives have a prevalence of the heterozygous genotype (Ser49Gly) of ADRB1 gene compared with the control group: 15 (50.0%) probands and 11 (44.0%) relatives, respectively, and 38 (19.2%) in the control group (p < 0.05). Significant prevalence of heterozygous genotype (Ser49Gly) of ADRB1 gene was observed in patients of the second subgroup with secondary AF: 14 (46.7%) persons in comparison with 38 (19.2%) persons of the control group (p < 0.05). CONCLUSION: Heterozygous genotype (Ser49Gly) of ADRB1 gene can be considered as one of the genetic predictors for development of primary or secondary AF. Relatives of probands with primary AF and genotype Ser49Gly should be included in the risk group for developing AF.
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Nicoulina et al. (2010) conducted a case-control in Atrial fibrillation. Heterozygous genotype (Ser49Gly) of ADRB1 gene vs. Control group was evaluated on Prevalence of the heterozygous genotype (Ser49Gly) of ADRB1 gene (p=< 0.05). The heterozygous genotype (Ser49Gly) of the ADRB1 gene was significantly more prevalent in probands with primary atrial fibrillation (50.0%) compared to controls (19.2%; p<0.05).
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