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February 26, 2002Proceedings of the National Academy of SciencesOpen Access

Genomic DNA breakpoints in AML1 / RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia

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Authors

YZYanming ZhangXuzhou Medical CollegePSPamela L. StrisselUniversity of Maryland, BaltimoreRSReiner StrickFriedrich-Alexander-Universität Erlangen-Nürnberg

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Zhang et al. (2002) studied this question.

synapsesocial.com/papers/6a97c0b8e6df4f2d123665cchttps://doi.org/10.1073/pnas.042702899
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.1991 · 894 citations
  2. 2DNA Cleavage within theMLLBreakpoint Cluster Region Is a Specific Event Which Occurs as Part of Higher-Order Chromatin Fragmentation during the Initial Stages of Apoptosis1997 · 180 citations