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The rates of matrix and bone formation and bone resorption were measured histologically in the tibial diaphysis of thyroparathyroidectomized rats. Compared to control animals, the rates of matrix and bone formation and bone resorption both were decreased significantly in rats given 3 Hirsch units of calcitonin every 8 hr for 6 days. The magnitude of the decrease of resorption was 68%, that of bone formation was 24%, and that of matrix formation was 22%. (Endocrinology 84: 261, 1969)
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Baylink et al. (1969) studied this question.
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