Aspirin was administered to 7 mildly diabetic rats which were force-fed a medium carbohydrate diet. The dose was 40. 80. and 160 mg of the drug per day. A marked amelioration of the glycosuria together with a gain in weight was noted in each rat. When the drug was withdrawn, there was exacerbation of the glycosuria to significantly higher levels than were noted during the pre-injection period, and there was an accompanying loss of weight.
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D. J. Ingle (1950) studied this question.