Key result
Sleep loss associated with decreased serotonergic activity is hypothesized to play a significant role in attempted suicide, suggesting sufficient sleep as a potential preventive factor.
This review proposes a hypothesis linking sleep loss and decreased serotonergic activity to attempted suicide.
Hypothesis-generating link between sleep loss, serotonergic activity, and suicide attempts; prospective trials needed before clinical consideration.
The author hypothesizes that sleep loss associated with a decrease in serotonergic activity plays a significant role in attempted suicide. Recent research has emphasized the role of the economic recession on the occurrence of suicide, but with no attention paid to possible biological aspects. In this brief review, the association between sleep, the serotonergic system, and suicide is initially introduced. Then, with consideration of recent research, a hypothesis regarding the oc- currence of suicide is proposed. Finally, based on that hypothesis, three factors possibly germane to reducing suicides (sufficient sleep duration, activation of the serotonergic system, and activation of the prefrontal cortex) are discussed.
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Jun Kohyama (2012) conducted a review in Suicide. Sleep loss and decreased serotonergic activity was evaluated on Attempted suicide. Sleep loss associated with decreased serotonergic activity is hypothesized to play a significant role in attempted suicide, suggesting sufficient sleep as a potential preventive factor.
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