Key result
Endothelial cells of vein grafts are derived from circulating progenitor cells, which are reduced by hyperlipidemia in apoE-deficient mice, correlating with enhanced atherosclerosis.
Population
Transgenic mice carrying LacZ genes driven by an endothelial TIE2 promoter, wild-type mice, chimeric mice…
Comparison
Vein fragment isografting into the carotid artery vs Different donor/recipient combinations…
Design
Preclinical
Follow-up
up to 4 weeks
Authors
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Supports circulating progenitor contribution to vein graft repair; hypothesis-generating for human interventions targeting progenitor mobilization.
Endothelial regeneration in vein grafts is driven by circulating progenitor cells, a process that is impaired in hyperlipidemic apoE-deficient mice.
Xu et al. (2003) studied Vein graft atherosclerosis. Vein isografting vs. Wild-type controls was evaluated on Endothelial cell regeneration and origin. Endothelial cells of vein grafts are derived from circulating progenitor cells, which are reduced by hyperlipidemia in apoE-deficient mice, correlating with enhanced atherosclerosis.
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