Immobilized bovine serum albumin (BSA) binds tannins selectively at pH 4. Monomeric polyphenolic substances such as gallic acid, chlorogenic acid and catechol do not interact with the protein under these conditions. The protein‐tannin complexes are dissociated by organic solvents such as methanol or dimethylformamide and the released tannins may be recovered in pure form. These principles have been utilized in the design of an analytical method which utilizes small columns of Sepharose‐BSA to achieve separation between the two groups of compounds.
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Hoff et al. (1977) studied this question.
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