Key result
High homocysteine levels (≥ 18.54 umol/L) were significantly associated with the prognosis of elderly patients with acute ischemic stroke treated with rtPA (P<0.05).
Why the study?
The relationship between homocysteine levels and prognosis in elderly patients with acute ischemic stroke treated with rtPA is poorly understood.
Does homocysteine level affect the prognosis in elderly patients with acute ischemic stroke treated with rtPA?
Cohort (n=120)
No
Does homocysteine level affect the prognosis in elderly patients with acute ischemic stroke treated with rtPA?
p-value: p=< 0.05
Homocysteine levels are significantly associated with the prognosis of elderly patients with acute ischemic stroke undergoing thrombolytic therapy.
High homocysteine may signal worse prognosis in elderly rtPA-treated AIS; hypothesis-generating and should not change practice.
BACKGROUND: Acute ischemic stroke (AIS) is mainly caused by cerebral blood flow disorders, which further leads to ischemic brain necrosis or encephalomalacia. The role of homocysteine (Hcy), an independent risk factor for cardiovascular disease, in the development of atherosclerosis is gradually revealed. However, studies are still rare and little is known about the relationship of Hcy level with the prognosis. AIM: To explore the relationship between Hcy level and prognosis in elderly patients with AIS after thrombolytic therapy with recombinant tissue plasminogen activator (rtPA). METHODS: A total of 120 patients with acute ischemic stroke who were admitted to Jingzhou Central Hospital and underwent recombinant tissue plasminogen activator treatment were randomly selected from January 2017 to December 2018. They were divided into two groups according to the level of Hcy, with 60 patients in each group. Patients with Hcy ≥ 18.54 umol/L were included into a high-level group and those with Hcy < 18.54 umol/L were included into a low-level group. The outcomes were analyzed in the two groups after the treatment. RESULTS: < 0.05). CONCLUSION: The level of Hcy is closely related to the prognosis of elderly patients with acute ischemic stroke, and after rtPA treatment, the prognosis of elderly patients is improved significantly.
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Li et al. (2019) conducted a cohort in Acute ischemic stroke (n=120). High homocysteine level (≥ 18.54 umol/L) vs. Low homocysteine level (< 18.54 umol/L) was evaluated on Prognosis (p=< 0.05). High homocysteine levels (≥ 18.54 umol/L) were significantly associated with the prognosis of elderly patients with acute ischemic stroke treated with rtPA (P<0.05).
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