Key result
Serum homocysteine, total protein, triglycerides, and LDL were significantly higher, while HDL was significantly lower, in patients with coronary heart disease compared to healthy controls.
Why the study?
Do serum homocysteine and blood lipid levels correlate with the presence and severity of coronary heart disease?
Case-Control (n=200)
No
Do serum homocysteine and blood lipid levels correlate with the presence and severity of coronary heart disease?
Combined detection of serum homocysteine and blood lipid levels provides diagnostic value for assessing the presence and severity of coronary heart disease.
Elevated Hcy and lipids track CHD severity without mutual correlation; leaves open whether combined testing adds diagnostic value beyond current risk models.
Objective: The incidence of coronary heart disease is rapidly rising in China. The relationship of serum homocysteine (Hcy) and blood lipid levels with Coronary Heart Disease (CHD) is still controversy. This study analysed the relationship of serum Hcy and blood lipid level in different types of CHD. Patients and Methods: A total of 100 cases of CHD patients in different types and healthy volunteers were selected. Serum Hcy, Triglyceride (TG), High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL) were measured. The levels of serum Hcy and blood lipid levels were compared in CHD patients with different clinical types, vascular lesions, and coronary stenosis by chi-square test. The sensitivity and specificity of serum Hcy and blood lipid levels in CHD were evaluated. The relationship between serum Hcy and blood lipid levels were analysed by linear regression analysis. Results: Hcy, TP, TG, and LDL were significantly higher, while HDL level was obviously lower in experimental group compared with control (P<0.05). The levels of serum Hcy, TP, TG, and LDL gradually increased, whereas HDL level gradually declined among SAP, UAP, and AMI patients, in single vessel disease group, double vessels disease group, and multivessel disease group, and in patients with mild, moderate, severe stenosis, and entirely occlusion (P<0.05). Serum HDL exhibited high sensitivity, while serum Hcy presented high specificity. Conclusion: Hcy and blood lipid levels increased in CHD. Hcy and blood lipid level exhibited no correlation with each other. Their combination detection is of diagnostic value to CHD.
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Zhang et al. (2018) conducted a case-control in Coronary Atherosclerotic Heart Disease (CHD) (n=200). Serum homocysteine and blood lipid levels vs. Healthy volunteers was evaluated on Differences in serum homocysteine and blood lipid levels between CHD patients and healthy controls (p=<0.05). Serum homocysteine, total protein, triglycerides, and LDL were significantly higher, while HDL was significantly lower, in patients with coronary heart disease compared to healthy controls.
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