Key result
Addition of a calcium ionophore (A23187) to a hypotonic perfusate decreased glomerular pressure by 16 +/- 1.1 mmHg, compared to 6 +/- 0.8 mmHg with hypotonic solution alone.
Why the study?
Does activation of macula densa cytoplasmic calcium mediate tubulo-glomerular feedback responses in rats?
Does activation of macula densa cytoplasmic calcium mediate tubulo-glomerular feedback responses in rats?
Cytoplasmic calcium within macula densa receptor cells appears to participate in the transmission of tubulo-glomerular feedback signals to contractile cells.
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May implicate macula densa calcium in rat TGF; leaves open human translation or therapeutic relevance.
Bell et al. (1982) studied Tubulo-glomerular feedback. Calcium ionophore (A23187) in hypotonic solution vs. Hypotonic solution alone or calcium-free solution with A23187 was evaluated on Glomerular pressure. Addition of a calcium ionophore (A23187) to a hypotonic perfusate decreased glomerular pressure by 16 +/- 1.1 mmHg, compared to 6 +/- 0.8 mmHg with hypotonic solution alone.
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