March 1, 2015Bulletin of the Veterinary Institute in PulawyOpen Access

Pathomorphological Changes of the Myocardium in Canine Dilated Cardiomyopathy (DCM)

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Dilated cardiomyopathy (DCM) (n=11). Intervention: Dilated cardiomyopathy. Primary outcome: Pathomorphological changes (fibrosis, fatty infiltration, vascular changes, degenerative changes, inflammatory infiltrates) in ventricular and atrial walls.

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Key result

Histopathological evaluation of hearts from dogs with dilated cardiomyopathy revealed complex structural changes, including fibrosis and cardiomyocyte degeneration, in both ventricular and atrial muscles.

Authors

IJI. JanusWrocław University of Environmental and Life Sciences MNMarcin NowakWrocław University of Environmental and Life Sciences JMJ.A. MadejUniversity of Life Sciences in Poznań

Discussion

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Implication

Supports comprehensive atrial assessment in canine DCM; hypothesis-generating for progression and therapeutic studies.

Study Design

Type

Observational (n=11)

PICO

Population

11 dogs (mean age 7.4 years, 36.4% female) with clinically diagnosed dilated cardiomyopathy whose hearts were evaluated post-mortem.

Exposure / Comparator

Dilated cardiomyopathy

Primary Outcome

Pathomorphological changes (fibrosis, fatty infiltration, vascular changes, degenerative changes, inflammatory infiltrates) in ventricular and atrial walls

Limitations

Small sample size
Inability to determine whether myocardial processes are primary or secondary to heart failure

Cite This Study

Janus et al. (2015) conducted an observational in Dilated cardiomyopathy (DCM) (n=11). Dilated cardiomyopathy was evaluated on Pathomorphological changes (fibrosis, fatty infiltration, vascular changes, degenerative changes, inflammatory infiltrates) in ventricular and atrial walls. Histopathological evaluation of hearts from dogs with dilated cardiomyopathy revealed complex structural changes, including fibrosis and cardiomyocyte degeneration, in both ventricular and atrial muscles.

synapsesocial.com/papers/6a97c9b748723bb28e366b85 https://doi.org/10.1515/bvip-2015-0020

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Pathomorphological Changes of the Myocardium in Canine Dilated Cardiomyopathy (DCM)

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Pathomorphological Changes of the Myocardium in Canine Dilated Cardiomyopathy (DCM)

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Also Consider

Also Consider