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Lighting up tumours in vivo: Activatable probes are designed to image tumour targets and cell internalisation in mice, with improved image contrast. These activatable probes are built on a cyclodecapeptide template with two independent functional domains. The cell-targeting domain allows a multimeric presentation of the RGD motif, and the imaging domain is composed of a dye and a quencher, separated by an intracellular cleavable disulfide bound.
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Razkin et al. (2006) studied this question.
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