Key result
Using subject-specific hemodynamic response functions significantly improved the detection sensitivity of prefrontal pain response compared to a standard HRF.
Why the study?
Does a GLM-based detection model using subject-specific HRFs improve the detection sensitivity of aPFC pain response compared to a standard HRF in subjects undergoing fNIRS?
Does a GLM-based detection model using subject-specific HRFs improve the detection sensitivity of aPFC pain response compared to a standard HRF in subjects undergoing fNIRS?
Using subject-specific hemodynamic response functions significantly improves the sensitivity of fNIRS in objectively detecting pain responses in the anterior prefrontal cortex.
Currently, there is no method for providing a nonverbal objective assessment of pain. Recent work using functional near-infrared spectroscopy (fNIRS) has revealed its potential for objective measures. We conducted two fNIRS scans separated by 30 min and measured the hemodynamic response to the electrical noxious and innocuous stimuli over the anterior prefrontal cortex (aPFC) in 14 subjects. Based on the estimated hemodynamic response functions (HRFs), we first evaluated the test-retest reliability of using fNIRS in measuring the pain response over the aPFC. We then proposed a general linear model (GLM)-based detection model that employs the subject-specific HRFs from the first scan to detect the pain response in the second scan. Our results indicate that fNIRS has a reasonable reliability in detecting the hemodynamic changes associated with noxious events, especially in the medial portion of the aPFC. Compared with a standard HRF with a fixed shape, including the subject-specific HRFs in the GLM allows for a significant improvement in the detection sensitivity of aPFC pain response. This study supports the potential application of individualized analysis in using fNIRS and provides a robust model to perform objective determination of pain perception.
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Peng et al. (2017) studied Pain (n=14). Subject-specific hemodynamic response functions (HRFs) vs. Standard HRF with a fixed shape was evaluated on Detection sensitivity of aPFC pain response. Using subject-specific hemodynamic response functions significantly improved the detection sensitivity of prefrontal pain response compared to a standard HRF.
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