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March 9, 2006Journal of General Virology

Genetic and antigenic diversity among noroviruses

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Key result

Polyclonal antisera raised against 26 different norovirus virus-like particles demonstrated novel broad-range cross-reactivities among different genotypes driven by conserved amino acid residues.

Population

26 different Norovirus virus-like particles (VLPs) representing six GI and 12 GII genotypes

Design

Preclinical

Authors

GHGrant S. HansmanGriffith UniversityKNKatsuro NatoriNational Institutes of HealthHSHaruko Shirato-HorikoshiNational Institutes of Health

Discussion

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Implication

Informs norovirus vaccine epitope selection; leaves open human protection from animal antisera cross-reactivity.

Structured PICO

P
Population
26 different Norovirus virus-like particles (VLPs) representing six GI and 12 GII genotypes
E
Exposure
Antibody ELISA using polyclonal antisera raised against the VLPs
O
Outcome
Cross-reactivity among different NoV VLPssurrogate

Broad-range cross-reactivities among norovirus genotypes are influenced by conserved amino acid residues and VP1 secondary structures.

Cite This Study

Hansman et al. (2006) studied Norovirus. Cross-reactivity analysis of NoV VLPs was evaluated on Antigenic cross-reactivity. Polyclonal antisera raised against 26 different norovirus virus-like particles demonstrated novel broad-range cross-reactivities among different genotypes driven by conserved amino acid residues.

synapsesocial.com/papers/6a97cece44220fce7874bda1https://doi.org/10.1099/vir.0.81532-0
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