Key result
Postoperative antiplatelet agents did not significantly alter prothrombotic biomarkers up to 6 months following endovascular abdominal aortic aneurysm repair.
Why the study?
Do postoperative antiplatelet agents reduce prothrombotic diathesis biomarkers in patients following elective endovascular abdominal aortic aneurysm repair?
Cohort (n=40)
Do postoperative antiplatelet agents reduce prothrombotic diathesis biomarkers in patients following elective endovascular abdominal aortic aneurysm repair?
Postoperative antiplatelet therapy does not significantly alter the prothrombotic diathesis (as measured by coagulation biomarkers) in patients following elective EVAR.
Answers are grounded in this paper and cite their sources.
No biomarker effect seen with antiplatelet agents; leaves open their role in post-EVAR thrombotic risk.
Prothrombotic diathesis expressed by elevated levels of coagulation-specific biomarkers has been reported in patients with abdominal aortic aneurysm (AAA) and after AAA endovascular repair (EVAR). This study investigates the effect of antiplatelet agents (APLs) on the prothrombotic diathesis in the post-EVAR period. Forty elective EVAR patients had thrombin-antithrombin complex, d-dimer, fibrinopeptide A, and high-sensitivity C-reactive protein measured before, at 24 hours, 1 month, and 6 months after EVAR. Patients receiving APLs postoperatively were compared with those not receiving APLs. All biomarkers were above the normal limits preoperatively and increased significantly 24 hours postoperatively followed by a drop at 1 and 6 months. No statistically significant changes were noted among patients receiving APLs in comparison with those not receiving APLs. The preoperative and postoperative prothrombotic diathesis of AAA following EVAR was confirmed in line with other reports. There was however no significant alteration of the examined biomarkers in patients receiving APLs.
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Trellopoulos et al. (2013) conducted a cohort in Abdominal aortic aneurysm (AAA) (n=40). Antiplatelet agents vs. No antiplatelet agents was evaluated on Levels of thrombin-antithrombin complex, d-dimer, fibrinopeptide A, and high-sensitivity C-reactive protein. Postoperative antiplatelet agents did not significantly alter prothrombotic biomarkers up to 6 months following endovascular abdominal aortic aneurysm repair.
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