Key result
Fibrinolysis with streptokinase resulted in a 9.6% mortality rate compared to 16.6% for redo surgery in patients with mechanical prosthetic valve thrombosis, which was not statistically significant.
Why the study?
The study was conducted to evaluate the characteristics and clinical outcomes of patients presenting with mechanical prosthetic valve thrombosis at a tertiary cardiac center in Pakistan.
Population
70 patients presenting with mechanical prosthetic valve thrombosis
Comparison
Streptokinase vs redo surgery vs heparin
Design
Prospective, interventional study
Authors
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Provides insights into prosthetic valve thrombosis in Pakistan; leaves open optimal therapy selection.
Cohort (n=70)
No
Absolute Event Rate: 9.6% vs 16.6%
p-value: p=>0.05
Khan et al. (2020) conducted a cohort in Mechanical prosthetic valve thrombosis (n=70). Fibrinolytic therapy (streptokinase) vs. Redo surgery was evaluated on Mortality (p=>0.05). Fibrinolysis with streptokinase resulted in a 9.6% mortality rate compared to 16.6% for redo surgery in patients with mechanical prosthetic valve thrombosis, which was not statistically significant.
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