Normal phase HPLC methodology was utilised to obtain separation of (±)-1-(4-bromophenyl)ethylamine and (±)-1-(1-Naphthyl)ethylamine on a 3,5- dinitrobenzoyl-(S)-Leucine Pirkle type chiral stationary phase (CSP). A proposed retention mechanism (based on a three point interaction model) is outlined where the key interaction is steric attraction/repulsion between aryl groups on the solutes and the (S) Leucine group on the CSP.
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Morris et al. (1996) studied this question.
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