Key result
Hypertensive obese type 2 diabetic females had a significantly higher atherogenic lipid profile, including a higher TC/HDL-C ratio (8.16 vs 5.90, p=0.001), compared to hypertensive obese non-diabetic females.
Cross-Sectional (n=446)
Obese hypertensive type 2 diabetic females exhibit a more profound atherogenic dyslipidemia profile compared to males and non-diabetic counterparts.
INTRODUCTION: Hypertension and obesity are common problems among diabetic patients accelerating progression of vascular diabetic complications. MATERIALS AND METHODS: A two-stage stratified random sampling design was used, and individuals aged 15 years and over were interviewed. This cross-sectional study evaluated lipid abnormalities of 117 obese type 2 diabetic patients (28 males and 89 females), and 56 hypertensive obese type 2 diabetic patients (22 males and 34 females). Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were assayed using standard biochemical methods. RESULTS: Hypertensive obese type 2 diabetic females had significantly higher mean serum concentrations of TC (p = 0.043), TG (p = 0.046), LDL-C (p= 0.040), TC/HDL-C ratio (p = 0.001) and LDL-C/HDL-C ratio (p = 0.003) compared with hypertensive obese non-diabetic females. Similar results were found in hypertensive obese type 2 diabetic males compared with hypertensive obese non-diabetic males. Hypertensive obese type 2 diabetic females had significantly higher serum TC, TG and TC/HDL-C ratio (p < 0.05) than hypertensive obese type 2 diabetic males. Hypertensive obese type 2 diabetic females had significantly higher mean serum concentrations of TG (p = 0.03) and TC (p = 0.01) than obese type 2 diabetic females. There was a significant association between blood glucose and LDL-C concentrations in type 2 diabetic subjects (r = 0.36; p< 0.05). CONCLUSION: Obese hypertensive type 2 diabetic females are exposed more profoundly to risk factors including atherogenic dyslipidaemia compared with males.
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Gordon et al. (2010) conducted a cross-sectional in Obesity, Type 2 Diabetes Mellitus, Hypertension (n=446). Type 2 diabetes vs. Non-diabetic subjects was evaluated on TC/HDL-C ratio in hypertensive obese females (p=0.001). Hypertensive obese type 2 diabetic females had a significantly higher atherogenic lipid profile, including a higher TC/HDL-C ratio (8.16 vs 5.90, p=0.001), compared to hypertensive obese non-diabetic females.
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