Key result
1H NMR metabolic profiling of deproteinized serum differentiated female from male patients with suspected cardiovascular disease with 80% accuracy (p=0.039), driven by higher lactate and glucose levels in women.
Why the study?
Sex influences the metabolic profile and hampers metabolomic translation to the clinic, motivating investigation of sex-associated differences in the 1H NMR metabolic profile beyond lipoproteins.
Cross-Sectional (n=39)
No
p-value: p=0.039
Sex-related differences in the 1H NMR metabolic profile (including lactate, glucose, and lipoproteins) exist in patients with suspected cardiovascular disease, highlighting the need to account for sex in metabolomic risk stratification.
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Sex differences in NMR metabolites support accounting for sex in future CVD models; leaves open whether profiles improve risk prediction.
Barba et al. (2019) conducted a cross-sectional in Suspected coronary artery disease (n=39). Female sex vs. Male sex was evaluated on Sex classification accuracy using OPLS-DA model on deproteinized serum spectra (p=0.039). 1H NMR metabolic profiling of deproteinized serum differentiated female from male patients with suspected cardiovascular disease with 80% accuracy (p=0.039), driven by higher lactate and glucose levels in women.
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