The Determination of the Dissociation Constants of Picric Acid and 2,2′,4,4′,6,6′-Hexanitrodiphenylamine in Ketone–Water Mixtures

The acid dissociation constants, Ka, of picric acid and 2,2′,4,4′,6,6′-hexanitrodiphenylamine in acetone, ethyl methyl ketone, and isobutyl methyl ketone were determined in the presence of water. The pKa values increased remarkably with a decrease in the water content. The pKa values in water-free ketones were estimated.