Oxacillin and Hepatotoxicity

Letters and Corrections1 March 1979Oxacillin and HepatotoxicityLAWRENCE J. D'ANGELO, M.D.LAWRENCE J. D'ANGELO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-442_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report of Onorata and Axelrod in the October issue (1) emphasizes the otherwise poorly recognized risk of hepatotoxicity from high-dose intravenous oxacillin. However, while I agree that this was probably the agent that induced the observed abnormalities in liver function, the authors' unfortunate statement that none of the other agents their patients were taking "have been associated with hepatic dysfunction" ironically makes them guilty of the same lack of vigilence that made their paper possible.Of the eight patients cited, six were taking other drugs theoretically capable of inducing injury similar to that seen in these...References1. ONORATO I and AXELROD J: Hepatitis from intravenous high-dose oxacillin therapy. Findings in an adult inpatient population. Ann Intern Med 89:497-500, 1978 LinkGoogle Scholar2. MECHANIC R and MEYERS L: Chloromazine-type cholangitis. Report of a case occurring after the administration of prochlorperazine. N Engl J Med 259:778-780, 1958 CrossrefMedlineGoogle Scholar3. KLATSKIN G: Toxic and drug-induced hepatitis, in Diseases of the Liver, 5th ed., edited by SCHIFF L. Philadelphia, JB. Lippincott Co., 1975, pp. 604-710 Google Scholar4. MITCHELL J, NESLON W, POTTER W, SASAME H, and JOLLOW D: Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite. J Pharmacol 199:41-52, 1976 Google Scholar5. MCLEAN A and DAY P: The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures. Biochem Pharmacol 24:37-42, 1975 CrossrefMedlineGoogle Scholar6. ZIMMERMAN H: Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. New York, Appleton-Century-Crofts, 1978, p. 577 Google Scholar1. MCFARLAND R: Fatal drug reaction associated with prochlorperazine (Compazine). Report of a case characterized by jaundice, thrombocytopenia, and agranulocytosis. Am J Clin Pathol 40:284, 1963 CrossrefMedlineGoogle Scholar2. KLATSKIN G: Toxic and drug-induced hepatitis, in Diseases of the Liver, 5th ed., edited by SCHIFF L. Philadelphia, J.B. Lippincott Co., 1975, pp. 604-710 Google Scholar3. JOHNSON G and TOLMAN K: Chronic liver disease and acetominophen. Ann Intern Med 87:302-304, 1977 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE J. D'ANGELO, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatotoxicity of Antimicrobials and Antifungal AgentsFlucloxacillin-induced Cholestatic Liver DamageFlucloxacillin-induced Cholestatic Liver Damage 1 March 1979Volume 90, Issue 3Page: 442-442KeywordsDrugsLiverRisk management ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...