Jaundice during Chlorpromazine Therapy

CHLORPROMAZINE hydrochloride, 10-(3-di-methylaminopropyl)-2-chlorphenothiazine hydrochloride, is being used, apparently with remarkable benefit, in the treatment of various neuropsychiatric disorders and as an antiemetic, analgesic and sedative.1 2 3 The following case is reported because of the occurrence of jaundice for which no cause besides chlorpromazine was found.Case ReportJ.M., a 70-year-old woman, was admitted to the hospital on May 24, 1954, because of jaundice. For 3 years she had had many episodes of mental depression, for which electroshock therapy had been given on several occasions. Because the depressed state persisted she had entered a private mental institution, where, on April 28, administration . . .