Key result
Delayed-enhancement MR imaging with an elastin-specific contrast agent improved the prediction of vulnerable plaque disruption compared to unenhanced T1-weighted black-blood imaging (sensitivity 83.7% vs 58.1%).
Why the study?
Does delayed-enhancement MR imaging with an elastin-specific contrast agent improve the assessment of vascular remodeling and prediction of vulnerable plaque compared to unenhanced black-blood MR imaging in a rabbit model of atherosclerosis?
Does delayed-enhancement MR imaging with an elastin-specific contrast agent improve the assessment of vascular remodeling and prediction of vulnerable plaque compared to unenhanced black-blood MR imaging in a rabbit model of atherosclerosis?
Absolute Event Rate: 83.7% vs 58.1%
Delayed-enhancement MR imaging with an elastin-specific contrast agent provides a more accurate assessment of vascular remodeling and better prediction of vulnerable plaques than unenhanced black-blood MR imaging in a preclinical model.
May improve plaque assessment in animal models; leaves open human translation and clinical validation.
PURPOSE: To compare delayed-enhancement (DE) magnetic resonance (MR) imaging with an elastin-specific contrast agent and unenhanced black-blood (BB) MR imaging with regard to vessel wall delineation and assessment of vascular remodeling and to test the prospective value for predicting plaque disruption in a rabbit model of atherosclerosis. MATERIALS AND METHODS: All procedures were approved by the animal ethics committee. Atherosclerosis was induced in 14 New Zealand White rabbits by means of a 1% cholesterol diet and endothelial denudation. Plaque disruption was triggered with Russell's viper venom and histamine. Animals with atherosclerosis were imaged before triggering to identify plaques and vascular remodeling and after triggering to identify thrombus. Plaques were classified as nondisrupted (stable) or disrupted (vulnerable). Control rabbits fed a regular diet were imaged twice. Unenhanced T1-weighted BB MR imaging, DE MR imaging with an elastin-specific contrast agent, and T1 mapping were used to assess vascular remodeling and calculate the plaque area and vessel wall relaxation rate (R1 = 1/T1). Elastin was quantified by using elastica-van Gieson stain. Group comparisons were analyzed with the Mann-Whitney or paired t test. Agreement between methods was performed with Bland-Altman analysis. RESULTS: Unenhanced T1-weighted BB MR imaging and DE MR imaging showed that, compared with nondisrupted plaques, disrupted plaques had larger plaque area (T1-weighted BB MR imaging: 5.1 mm(2) vs 5.7 mm(2); DE MR imaging: 6.0 mm(2) vs 7.9 mm(2); P < .001) and vessel area (T1-weighted BB MR imaging: 11.8 mm(2) vs 14.3 mm(2); DE MR imaging: 10.8 mm(2) vs 13.9 mm(2); P < .001) and underwent positive remodeling. Assessment of positive remodeling with DE MR imaging enabled better prediction of plaque disruption compared to that with unenhanced T1-weighted BB imaging (sensitivity: 83.7% vs 58.1%). DE MR imaging showed a stronger agreement with histologic findings, whereas the vessel area was overestimated with unenhanced T1-weighted BB imaging. CONCLUSION: Compared with unenhanced T1-weighted BB MR imaging, DE MR imaging with an elastin-specific contrast agent enables more accurate assessment of vascular remodeling in the prediction of vulnerable plaque.
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Phinikaridou et al. (2014) studied Atherosclerosis (n=14). Delayed-enhancement MR imaging with an elastin-specific contrast agent vs. Unenhanced T1-weighted black-blood MR imaging was evaluated on Prediction of plaque disruption (sensitivity). Delayed-enhancement MR imaging with an elastin-specific contrast agent improved the prediction of vulnerable plaque disruption compared to unenhanced T1-weighted black-blood imaging (sensitivity 83.7% vs 58.1%).
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