Key result
Dazoxiben effectively inhibited thromboxane synthetase and increased 6-keto-PGF1 alpha formation by over 100%, but had a weaker effect on platelet reactivity than acetylsalicylic acid.
Why the study?
Does dazoxiben or acetylsalicylic acid affect platelet function and prostaglandin metabolism in men?
Population
24 men
Comparison
Dazoxiben 0.1 g or acetylsalicylic acid 0.25 g… vs Placebo
Design
Other
Authors
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Dazoxiben may provide weaker platelet inhibition than aspirin; leaves open whether selective thromboxane synthetase inhibition confers clinical benefit.
RCT (n=24)
Does dazoxiben or acetylsalicylic acid affect platelet function and prostaglandin metabolism in men?
Dazoxiben is a selective thromboxane synthetase inhibitor that increases prostacyclin metabolite levels but has a weaker antiplatelet effect than acetylsalicylic acid.
Dale et al. (1983) reported an RCT. Dazoxiben and Acetylsalicylic Acid vs. Placebo was evaluated on Platelet function and prostaglandin metabolism. Dazoxiben effectively inhibited thromboxane synthetase and increased 6-keto-PGF1 alpha formation by over 100%, but had a weaker effect on platelet reactivity than acetylsalicylic acid.
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