A method of recording changes in bone blood-flow using a heated thermocouple is described. 2. Occlusion of the femoral artery or aorta decreases the blood-flow in the femoral metaphysis. 3. Occlusion of the femoral vein and intravenous injection of adrenaline, nor-adrenaline, acetylcholine, histamine or hexamethonium bromide increase the blood-flow in the femoral metaphysis.
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McPherson et al. (1961) studied this question.