The effect of methotrexate on the phagocytosis and killing of Staphylococcus aureus by granulocytes from healthy blood donors was investigated in vitro. A concentration of methotrexate of 2.2 x 10(-4) mol/1 (100 micrograms/ml), which is readily obtained on high dose intravenous administration did not decrease the phagocytosis and intracellular killing of Staph. aureus. In addition, granulocytes isolated from patients after termination of 6 h and 24 h high-dose methotrexate infusions showed normal phagocytic activity.
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Marhaug et al. (1980) studied this question.
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