Thiomarinols D, E, F and G, New Hybrid Antimicrobial Antibiotics Produced by a Marine Bacterium;Isolation, Structure, and Antimicrobial Activity.

In our previous papers, we reported newantibiotics, thiomarinol A (TMA, 1)1} and minor components thiomarinols B (TMB, 2) and C (TMC, 3)2), which were isolated from the culture broth of a marine bacterium, Alteromonas rava sp.nov.SANK73390.ThiomarinolsA and C are hybrid antibiotics composed of a pseudomonic acid analogue and holothin3).In this paper, we report isolation, structure elucidation and antimicrobial activities of new minor components, thiomarinols D (TMD), E (TME), F (TMF) and G (TMG).